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KMID : 1188320120060010058
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Gut and Liver
2012 Volume.6 No. 1 p.58 ~ p.63
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The Feasibility and Safety of the Endoscopic Submucosal Dissection of Superficial Gastric Neoplastic Lesions in Patients with Compensated Liver Cirrhosis: A Retrospective Study
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Choi Jong-Hak
Kim Eun-Ran
Min Byung-Hoon
Choi Dong-Il
Kang Ki-Joo
Lee Jun-Haeng
Rhee Poong-Lyul
Kim Jae J.
Rhee Jong-Chul
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Abstract
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Background/Aims:When undergoing endoscopic submucosal dissection (ESD), patients with liver cirrhosis (LC) may suffer from a high risk of bleeding, bacteremia and tissue vulnerability. There have been few reports evaluating the efficacy and safety of ESD in patients with LC.
Methods:From January 2004 to March 2010, 23 patients with LC (cirrhosis group) underwent ESD for superficial gastric neoplastic lesions. The number of patients with a liver function in the Child-Pugh classes A and B were 20 and 3, respectively. The clinical outcomes and complications were compared with 69 patients without LC (control group) that were matched for age and sex.
Results:The en bloc resection, R0 resection and en bloc plus R0 resection rates of the cirrhosis group were 82.6%, 91.3%, and 82.6%, respectively, and did not show significant differences from the rates of the control group. No local recurrence was found in either group during the follow-up period. The procedure length of time (41.0 vs 39.0 minutes), rate of bleeding (4.3% vs 7.2%) and rate of perforation (0.0% vs 1.4%) in the cirrhosis group were also comparable to the results from the control group.
Conclusions:ESD was safely performed in patients with LC, and satisfactory outcomes were achieved with high en bloc and R0 resection rates for superficial gastric neoplastic lesions.
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KEYWORD
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Superficial gastric neoplastic lesion, Endoscopic submucosal dissection, Liver cirrhosis
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